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Chitlange, S. S.
- Development and Validation of Stability-Indicating HPTLC Method for Analysis of Amlodipine Besilate, Losartan Potassium and Hydrochlorothiazide in Pharmaceutical Dosage Form
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Padmashri Dr. D. Y. Patil Institute of Pharmaceutical Sciences band Research, Sant Tukaram Nagar, Pimpri, Pune-411018, IN
1 Department of Pharmaceutical Chemistry, Padmashri Dr. D. Y. Patil Institute of Pharmaceutical Sciences band Research, Sant Tukaram Nagar, Pimpri, Pune-411018, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 2 (2010), Pagination: 60-62Abstract
The present work describes a stability-indicating HPTLC method for simultaneous analysis of Amlodipine besilate (AMLO), Losartan Potassium (LOS) and Hydrochlorothiazide (HCTZ) in bulk and pharmaceutical dosage form. Aluminium plate precoated with silica gel 60 F254 was used as stationary phase. The separation was carried out using chloroform: ethyl acetate: methanol: ammonia (4: 4: 2:0.2 v/v/v/v) as mobile phase. The densitometric scanning was carried out at 232 nm. The linearity was obtained in the range 100-800 ng per band for amlodipine besilate (Correlation coefficient: 0.9954), 400-2400 ng per band for hydrochlorothiazide (Correlation coefficient: 0.9952) and 1000-8000 ng per band for losartan potassium (Correlation coefficient: 0.9947). The method was validated as per ICH guidelines. The combined dose tablet formulation was subjected to forced degradation by acid, alkali, oxidation, dry heat and exposure to ultraviolet radiations at 254 nm. The degradation products were well resolved from the pure drug with significantly different Rf values.Keywords
Amlodipine Besilate (AMLO), Losartan Potassium (LOS), Hydrochlorothiazide (HCTZ), HPTLC, Validation, Stability Studies.Full Text
- Simultaneous Spectrophotometric Estimation of Ofloxacin and Satranidazole in Tablet Dosage Form
Abstract Views :170 |
PDF Views:0
Authors
Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18, IN
Source
Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 9-11Abstract
Two accurate, precise, rapid and economical methods were developed for the estimation of Ofloxacin and Satranidazole in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 259.0 nm for Ofloxacin (zero cross for Satranidazole) and 227.0 nm for Satranidazole (zero cross for Ofloxacin). Second method is area under curve method; area under curve in the range of 292.5-282.5 nm (for Ofloxacin) and 325.0-315.0 nm (for Satranidazole) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 5-40 μg/ml for Ofloxacin and Satranidazole, both. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.Keywords
Ofloxacin, Satranidazole, Derivative Spectroscopy, Area Under Curve Method.
- Stability Indicating RP-HPLC Method for Simultaneous Estimation of Valsartan and Amlodipine in Capsule Formulation
Abstract Views :156 |
PDF Views:0
Authors
Affiliations
1 Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-411018, IN
2 S. N. Institute of Pharmacy, Pusad, IN
1 Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-411018, IN
2 S. N. Institute of Pharmacy, Pusad, IN
Source
Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 15-18Abstract
Present work describes a precise, accurate and reproducible Reverse phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of Amlodipine besylate (AMLB) and Valsartan (VAT) on RP C-18 Column (Kromasil, 250×4.6 mm) using acetonitrile:phosphate buffer (0.02M, pH 3.0), (56:44 v/v) as mobile phase at a flow rate of 1.0 ml/min and the detection wavelength was 234 nm. The retention time for AMLB and VAT was found to be 3.07 and 6.20 min, respectively. The method was also applied for the determination of AMLB and VAT in the presence of their degradation products formed under variety of stress conditions. Proposed method was validated for precision, accuracy, linearity range, robustness and ruggedness.Keywords
Amlodipine Besylate, Valsartan, Reverse Phase High Performance Liquid Chromatography, Stability Indicating Method.- Design and Screening of PPAR-γ Agonist based Isatin Derivatives and its Remarkable Activity as Anti-Cancer and Anti-Diabetic
Abstract Views :160 |
PDF Views:0
Authors
Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 2017-2026Abstract
Isatin are flexible compound, where it can be used for the preparation of a large number of substituted heterocyclic compounds, such as pyrazole, benzofuran, pyridazinone and sulphonamides. Sulphonamides is important class such as carbonic anhydrase inhibitors, antibacterial, antitumor, diuretic, hypo-glycemic, antidiabetic and anti-thyroid. In the past few decades, research has reached to the mark with an increased interest in capturing novel methodologies and targets that forcefully worked for the preparation isatin based sulphonamides derivatives. This review covers updated information of most of the active isatin based sulphonamides derivatives that have been shown considerable novel synthetic schemes as well as pharmacological and biological actions by targeting them on PPAR-γ agonist. From these considerations, ideas for future molecular modifications by different synthetic scheme leading to preparation of compounds with greater favorable pharmacological and biological properties may be derived.Keywords
Isatin Based Sulphonamides, PPAR-γ, Antitumor, Antidiabetic.References
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